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Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions--Andrieu etal.
In the study timeline section, the bars represent the study period (start of recruitment to end of follow-up for the primary analysis) and the plotted circles represent year of publication of the primary analysis.
Types of interventions tested are colour coded as follows: non-specific pharmacological (light blue); specific anti-Alzheimer's disease pharmacological (dark blue); cognitive training or activity (purple); physical exercise(light green); nutritional (red); and multidomain (dark green).
When two different endpoints are shown for the same trial, they are coprimary endpoints. The main result refers to the primary study analysis (ie, result for the primary endpoint).
*Study began in 1989. †Study began in 1995. ‡Both nutritional and pharmacological interventions were tested (separately). §Study end date not specified in publication or trial registry (and not deducible from information provided). ¶Both cognitive training and physical exercise interventions were tested (separately). ||Only one of the four interventions tested showed significant positive effects on the primary outcome measure compared with the control group. **Study period not specified in publication or trial registry (and not deducible from information provided).