The Peter Attia Drive podcast with Richard Isaacson, MD is long and in depth. Peter knows you are easily distracted and his team produces stellar show notes for quick reference. My schedule of 2 to 3 hour trail runs were made for the hypnotic focus of the format. Think of what you thought you knew--now consider it a palimpsest--seek the critical thoughts and evidence based logical thinking and change your mind...okay this sounds a little fandom-y but when you are surrounded by blather and self-aggrandizing listicles of how to be this or that--the truth can be like manna.
What is a prospective cohort study? The prospective part of the study describes subjects enrolled into a cohort or group that have not yet developed the outcome of interest. None of the subjects in the study below actually have been "diagnosed" with Alzheimer's disease--read the study design for clarity. Longitudinal (over a period of years) studies are needed to observe and identify potential risk factors or associations with disease outcomes.
The two genotypes are ApoE (epsilon 2, epsilon 3, and epsilon 4) and MTHRF C677 1298c:
- MTHFR A1298C = heterozygous mutation (one mutation)
- MTHFR C1298C = homozygous mutation (two mutations)
- MTHFR C677T + MTHFR A1298C = a compound heterozygous mutation
“Anyone with a brain is at risk for Alzheimer’s.” —Richard Isaacson